LIONS: Large-scale Integrative approach to unravel the complex relationships between differentiatiON and tumorigenesiS (2015-2019)
Coordinator: Mohamed ELATI, co-PIs: François RADVANYI, Jenny SOUTHGATE, Etienne BIRMELE, Charles LECELIER
The LIONS project is a 48-month project funded by INSERM-ITMO Cancer through the “National Cancer Plan 2014-2019” framework and brings together five research teams from France and the UK. It aims at developing a multi-scale systems biology approach to identify and compare the networks found in normal and tumor states, and thereby assess pathways that are conserved or altered in the tumor state. The underlying ideas is that tumor cells make use of many of the regulatory networks of normal cells for their migration, proliferation, the attraction of new vessels, and the maintenance of various differentiation states. We will apply this strategy to bladder cancer, a cancer derived from the bladder urothelium, because normal urothelium can be obtained and cultured at different stages of proliferation and differentiation.
Systems biology of integrin inhibition- induced apoptosis for novel glioblastoma treatment (2018-2021)
Coordinator: Monique DONTENWILL, co-PIs: Laurent BRINO, Mohamed ELATI
48-month project funded by the French National Cancer Institute (INCa) through the “Projets libres de recherche «Biologie et Sciences du Cancer»” call. Integrin expressions and pathways are critically deregulated in cancer cells and thus specific integrins make a major contribution to tumor growth and resistance to therapies. The goal of our project is therefore to combine loss of function screens based on the pooled CRISPR/Cas 9 and RNA interference technologies with large-scale network inference and modeling methods to more deeply understand the integrin biology and signaling pathway crosstalks. Our project proposes an innovative way to characterize synthetic lethal partners of α5 integrin inhibition which will be confirmed in pertinent in vitro and in vivo preclinical models.
AdaLab: Adaptive Automated Scientific Laboratory (2015-2018)
Coordinator: Larisa Soldatova, co-PIs: Ross King, Céline Rouveirol, Mohamed Elati, Jan Ramon
AdaLab, a project funded by the chist-era 4th call for research proposals, integrates the scientific method with 21st century automation technology, with the goal of making scientific discovery cheaper, faster and better. The project will run for 4 years from the 1st of April, 2015. A Robot Scientist is a physically implemented laboratory automation system that exploits techniques from the field of artificial intelligence to execute cycles of scientific experimentation. Our vision is that within 10 years many scientific discoveries will be made by teams of human and robot scientists, and that such collaborations between human and robot scientists will produce scientific knowledge more efficiently than either could alone.
Regulatory-metabolic engineering of yeast strains for production of valuable Lipid(2016-2019)
co-PIs: Jean-Marc Nicaud, Mohamed Elati
a project funded by the IDEX Paris Saclay (Programme Interdisciplinaire IDI) and brings together two research teams from Paris-Saclay (I3-BioNet and BIMLip (INRA-MICALIS), that led to the co-supervision of a PhD Student, Pauline Trébulle (2016-19) and more recently we are involved in EU Horizon 2020 CHASSY project.
List of all funded projects
|LIONs (ITMO-INSERM “Biologie des Systèmes et Cancer”)||Coordinator||2015-18||752k €||Project’s website|
|AdaLab (EC FP7 Chist-Era)||PI||2014-18||1400 k€||Project’s website|
|Synpathic (ANR)||Participant||2015-17||450k €||Project’s web page (ANR)|
|CREPE (PEPS BMI)||PI||2013-14||20k €||Project’s web page (CNRS)|
|SysCilia (EC FP7 HEALTH)||co-PI||2010-14||12000k €||Project’s website|
|INSIGhT (INCa, Cancéropole IdF)||PI||2010-13||446 k€||Project’s web page|
|GENNETEC (EC FP6 IST FET)||Participant||2007-09||1475k €||Project’s website|